Background and Aim: The aim search was to investigate the relationship between media literacy and information literacy of students of communication and information sciences and knowledge studies, and its impact on their entrepreneurial ability.

Methods: This is a survey correlational method. Population consists of postgraduate students in information science and knowledge and communication sciences at Tehran and Allameh Tabatabai University. Data was collected from two sources: library documents and questionnaires. First, library method was used to examine the theoretical foundations of media literacy, information literacy and entrepreneurship. Then, by careful examination of literature - based on the research model - a questionnaire created and distributed. Data was analyzed by  Independent One-Sample t-Test  and Spearman Rank Correlation Coefficient.

Results: Findings showed that the level of media literacy and information literacy of students is desirable and the level of characteristics of entrepreneurship is relatively desirable.

Conclusion: The Pearson Correlation test showed a significant relationship between the variables of media literacy and information literacy. The impact of information literacy on entrepreneurial ability was confirmed and the impact of media literacy on entrepreneurial ability was rejected.